Our group has contributed a review entitled Designed Enzymatic Cascades to the new Science of Synthesis Workbench Edition: Biocatalysis in Organic Synthesis. In this reference work (Editors: Kurt Faber, Wolf-Dieter Fessner, Nicholas Turner), renowned experts provide an extensive overview of the current state of the art in enzymatic methods for organic synthesis.
Biocatalysis is a high quality journal designed to have impact on the scientific, academic and industrial sectors. Researchers, working in the field of biochemical catalysis for environmental, health and energy applications can share here results of their work. New approaches such as genomics, proteomics and molecular engineering are welcome as well. The journal includes frontier research tools such as computational chemistry and bionanotechnology. Readers of Biocatalysiscan enjoy free access to the novelties and innovations in the field of biochemically catalyzed reactions.
We have describe the heterologous expression of the rhamnulose-1-phosphate aldolase from Thermotoga maritima (Rha-1PA Tm) and its functional characterization. This enzyme presents an optimum temperature at 95 ºC and furthermore, in contrast with other hyperthermophilic enzymes, it maintains a significant percentage of activity at room temperature. The enzyme displayed a great stability to extreme reaction conditions such as high temperatures (half-life of more than 3 h at 115 ºC) and the presence of different organic solvents. Besides, is a useful biocatalyst that is compatible with multi-enzyme systems for C-C bond formation involving mesophilic enzymes.
Hyperthermophilic aldolases as biocatalyst for C-C bond formation: Rhamnulose 1-phosphate aldolase from Thermotoga maritima. Oroz-Guinea, I., Sánchez-Moreno, I., Mena, M., García-Junceda, E. Appl. Microbiol. Biotechnol. Available online: 18-Oct-2014,
On 19 September, Isabel brilliantly defended his doctoral thesis entitled "Rhamnulose-1-phosphate Aldolase from Thermotoga maritima: Characterization and Applicability of a New Thermostable Biocatalyst for C-C Bond Formation". Isabel got the highest rating of Excellent Cum Laude.
Congratulations!
Pablo Escurín defended his Master Thesis entitled "Production of sulfotransferases enzymes for regioselective sulfation of chondroitin sulfate derivatives". Congrats!
